Guidance documents

WHO Manual on the treatment of diarrhea

Implementing the new recommendations on the clinical management of diarrhea

Diarrhea treatment guidelines

WHO / UNICEF joint statement on diarrhea treatment

Guidelines on integrated management of childhood illness

Technical updates of the guidelines on integrated management of childhood illness (IMCI)

Guidelines for the control of shigellosis

Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae type 1

Low risk of adverse effects from zinc supplementation

Low risk of adverse effects from zinc supplementation

Formative research manual provided by INCLEN

Introducing the zinc pill in a clinical trial: A manual on conducting formative research to identify key messages


izincg technical document

Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections: A review of the evidence. Food Nutr Bull. 2009 Mar;30(1 Suppl):S41-59.


systematic reviews

Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2016 Dec 20;12:CD005436. doi: 10.1002/14651858.CD005436.pub5.

Lamberti LM, Walker CL, Chan KY, Jian WY, Black RE. Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis. Nutrients. 2013 Nov 21;5(11):4715-40. doi: 10.3390/nu5114715.

Fischer Walker CL, Black RE. Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Int J Epidemiol. 2010 Apr;39 Suppl 1:i63-9. doi: 10.1093/ije/dyq023.

Patel A, Mamtani M, Dibley MJ, Badhoniya N, Kulkarni H. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review. PLoS One. 2010 Apr 28;5(4):e10386. doi: 10.1371/journal.pone.0010386.

Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics. 2008 Feb;121(2):326-36. doi: 10.1542/peds.2007-0921.

Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis. Pediatrics. 2007 Jun;119(6):1120-30.

Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr. 2000 Dec;72(6):1516-22.